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    Interacoustics AS auditory-steady state responses
    Auditory Steady State Responses, supplied by Interacoustics AS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on <t>ASSR</t> using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.
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    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on <t>ASSR</t> using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.
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    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on <t>ASSR</t> using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.
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    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on <t>ASSR</t> using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.
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    auditory steady-state responses  (Interacoustics AS)
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    Interacoustics AS auditory steady-state responses
    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on <t>ASSR</t> using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.
    Auditory Steady State Responses, supplied by Interacoustics AS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on ASSR using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.

    Journal: bioRxiv

    Article Title: Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction

    doi: 10.1101/2024.02.15.580421

    Figure Lengend Snippet: (A) Scheme showing the treatment regime used to study the effect of subchronic PCP on cognition using the T-Maze alternation task; on ASSR using electroencephalography (EEG); on local mPFC network using ex vivo electrophysiology (EPhys) and immunohistochemistry (IHC) of PV; on the long-range inputs from vHPC to mPFC using optogenetics; and on brain networks using functional ultrasound imaging (fUS). Different cohorts of mice were used for each experiment. (B) Percent of spontaneous alternation of vehicle- and PCP treated mice in the T-Maze task at day 21 (for Vh, mean spontaneous alternation: 70.3 ± 3.2 %, n= 9 mice; for PCP: 60.4 ± 8.9%, n= 15 mice; Mann-Whitney U test: U = 31.5, p = 0.03). (C) Heatmaps of phase-lock ratio (left) in 40 Hz ASSR from the mPFC of vehicle- and PCP treated animals and quantifications at day 24 (for Vh, mean ratio: 0.33 ± 0.046, n= 5 mice; for PCP: 0.462 ± 0.029, n= 9 mice; Mann-Whitney U test: U = 8, p = 0.0599) day 31 (for Vh, mean ratio: 0.27 ± 0.065, n= 6 mice; for PCP: 0.423 ± 0.035, n= 8 mice; Mann-Whitney U test: U = 7, p = 0.293); day 34 (for Vh, mean ratio: 0.32 ± 0.0627, n= 4 mice; for PCP: 0.3625 ± 0.030, n= 9 mice; Mann-Whitney U test: U = 12, p = 0.207) and day 40 (for Vh, mean ratio: 0.318 ± 0.071, n= 6 mice; for PCP: 0.318 ± 0.034, n= 9 mice; Mann-Whitney U test: U = 26, p = 0.964). Each dot is the quantification of a single animal.

    Article Snippet: Wireless recording of 40Hz auditory steady-state response (ASSR) was established using the Neurologger system (TSE Systems) and auditory stimuli generated with an audio generator (MED Associates Inc.).

    Techniques: Ex Vivo, Immunohistochemistry, Optogenetics, Functional Assay, Imaging, MANN-WHITNEY